Topology, Molecular Simulation, and Machine Learning as Routes to Exploring Structure and Phase Behavior in Molecular and Atomic Crystals

  • TH Department Online Seminar
  • Date: Jan 14, 2021
  • Time: 16:30 - 18:00
  • Speaker: Prof. Dr. Mark E. Tuckerman
  • Professor of Chemistry and Mathematics, Department of Chemistry, New York University, USA
  • Room: Join zoom meeting: https://tum-conf.zoom.us/j/69317054390 | Meeting ID: 693 1705 4390 | Passcode: 788618
Topology, Molecular Simulation, and Machine Learning as Routes to Exploring Structure and Phase Behavior in Molecular and Atomic Crystals
Organic molecular crystals frequently exist in multiple forms known as polymorphs. Structural differences between crystal polymorphs can affect desired properties, such as bioavailability of active pharmaceutical formulations, lethality of pesticides, or electrical conductivity of organic semiconductors.

Crystallization conditions can influence polymorph selection, making an experimentally driven hunt for polymorphs difficult. Such efforts are further complicated when polymorphs initially obtained under a particular experimental protocol “disappear” in favor of another polymorph in subsequent repetitions of the experiment. Consequently, theory and computation can potentially play a vital role in mapping the landscape of crystal polymorphism. Traditional crystal structure prediction methods face their own challenges, and therefore, new approaches are needed. In this talk, I will show, by leveraging concepts from mathematics, specifically geometry and topology, and statistical mechanics in combination with techniques of molecular simulation, traditional methods, and machine learning, that a new paradigm in crystal structure prediction may be emerging. Examples demonstrating prediction of structures of crystals, co-crystals, and phase transitions will be presented.



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